Excedrin Extra Strength combines three active ingredients to provide a strong over-the-counter medicine for headaches and other kinds of pain. It has a fast-acting formula that delivers extra strength headache relief. For some, relief starts in as little as 15 minutes –to help you get back to your day. Active ingredients: Acetaminophen 250mg Aspirin 250 mg –Non-Steroidal Anti-Inflammatory Drug (NSAID) Caffeine 65 mg